Mitt Romney, whose business success has become his defining credential in a year of economic anxiety, prepared Thursday to take aim at President Barack Obama as a failed steward of the U.S. balance sheet, following Mr. Romney’s acceptance of the Republican nomination for president.

Mr. Romney’s nationally televised speech will mark the culmination of a seven-year effort to convince Republicans that he is sufficiently conservative to represent his party, and that he can win over voters this fall with an appeal based on his competency, if not personal charm.

In his speech, Mr. Romney will say that “now is the time to restore the promise of America,” vowing to deliver 12 million new jobs and unify a divided country.

“Many Americans have given up on this president but they haven’t ever thought about giving up,” Mr. Romney was expected to say, according to speech excerpts. “Not on themselves. Not on each other. And not on America.”

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